The role of brca1 in response to chemotherapy

The loss of function of BRCA1 is associated with susceptibility to chemotherapy that damage DNA and may also be associated with resistance to taxane-based chemotherapy. However, prospective clinical trials are needed to evaluate the role of BRCA1 in response to chemotherapy, a new study concludes November 17 in the Journal of National Cancer Institute. BRCA1 mutations account for only 5% of breast cancer and ovarian cancer, but the loss of function mutations in BRCA1 confer a 82% risk of breast cancer and a 54% risk of ovarian cancer.
Operation of the BRCA1 gene, a cell more sensitive to chemotherapeutic agents that damage DNA, such as platinum-based compounds. In addition, BRCA1 has also been shown to be involved in regulating cell division and loss of the gene has been96%
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